Amazing Spider-Man (1963 1st Series) #361
First Printing. Direct Edition. First (full) appearance of Carnage in "Savage Genesis!" Part 1 of 3. Script by David Michelinie. Pencils by Mark Bagley. Inks by Randy Emberlin. Cover by Mark Bagley and Randy Emberlin.
Blood runs in the streets as a serial killer roams New York City! And as the web-slinger investigates the murders, he notices a very disturbing similarity to another killer's modus operandi! In a burned-out building in Brooklyn, the spectacular one comes face-to-face with his new homicidal foe...Carnage! Can the wall-crawler end Cletus Kasady's rampage in their very first encounter?